Osteoarthritis (OA) is a type of chronic joint disease that is characterized by the degeneration and loss of articular cartilage\nand hyperplasia of the synovium and subchondral bone. There is reasonable knowledge about articular cartilage physiology,\nbiochemistry, and chondrocyte metabolism. However, the etiology and pathogenesis of OA remain unclear and need urgent\nclarification to guide the early diagnosis and treatment of OA. Extracellular vesicles (EVs) are small membrane-linking particles\nthat are released from cells. In recent decades, several special biological properties have been found in EV, especially in terms of\ncartilage. Autophagy plays a critical role in the regulation of cellular homeostasis. Likewise, more and more research has gradually\nfocused on the effect of autophagy on chondrocyte proliferation and function in OA. The synthesis and release of EV are closely\nassociated with autophagy. At the same time, both EV and autophagy play a role in OA development. Based on the mechanism of\nEV and autophagy in OA development, EV may be beneficial in the early diagnosis of OA; on the other hand, the combination of\nEV and autophagy-related regulatory drugs may provide insight into possible OA therapeutic strategies.
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